Indiana is charting a bold course toward becoming one of the most AI-ready economies in the nation. Across healthcare, manufacturing, agriculture, and enterprise software, Indiana’s leading companies are embracing artificial intelligence to drive innovation, enhance productivity, and tackle some of society’s most complex challenges. With deep industry expertise, world-class research institutions, and a collaborative tech ecosystem, Indiana is not just adapting to AI. It’s helping shape the future of it.

Here’s how some of Indiana’s innovation leaders are powering this transformation:

Eli Lilly: Harnessing AI to Accelerate Drug Discovery

As a global pharmaceutical leader, Eli Lilly is using AI and machine learning to dramatically reduce drug development timelines and improve patient outcomes. From advanced data modeling to AI-driven clinical trials, Lilly is investing in digital capabilities that will define the next era of precision medicine, positioning Indiana at the forefront of AI in life sciences.

Cummins: Driving Smarter, Cleaner Power Solutions

Cummins is applying AI across its operations—from optimizing engine performance and predictive maintenance to accelerating its transition to low- and zero-emissions technologies like hydrogen and battery electric. As the company evolves into a clean tech leader, AI plays a pivotal role in advancing sustainable innovation in Indiana’s manufacturing sector.

Salesforce: Powering AI-First Digital Transformation

Salesforce, through its growing presence in Indianapolis and its legacy from ExactTarget, is enabling thousands of businesses to integrate AI into their customer experiences. The company’s rollout of AI-powered tools like Einstein is helping Indiana companies, from startups to enterprises, leverage generative AI, automation, and analytics to transform how they operate and grow.

Elanco: Advancing Animal Health Through Data and AI

Elanco is pioneering AI applications in animal health, using advanced analytics to improve disease prediction, optimize treatment plans, and support more sustainable livestock production. With its global headquarters in Indiana, Elanco is a key player in applying AI to food systems, veterinary science, and public health.

Corteva Agriscience: AI-Driven AgTech for the Future of Farming

Corteva is integrating AI into everything from precision agriculture and climate-resilient crops to digital platforms that empower farmers with real-time insights. Its investment in AI and data science is strengthening Indiana’s leadership in agtech and ensuring more efficient, productive, and sustainable food systems.

Elevance Health: Personalizing Healthcare with AI

Elevance Health (formerly Anthem) is at the leading edge of health AI. Using machine learning and predictive analytics, the company is delivering personalized care recommendations, optimizing care pathways, and reducing health disparities. As one of the largest health insurers in the country, Elevance Health’s digital innovation efforts are making Indiana a national center for AI in healthcare.

Rolls-Royce: Engineering AI for Aerospace and Defense

Rolls-Royce’s advanced manufacturing operations in Indiana are leveraging AI to enhance aerospace design, automate quality control, and improve engine efficiency. Their investments in AI-driven engineering and digital twin technology are critical to the future of aviation and national defense, and position Indiana as a leader in smart manufacturing and aerospace innovation.

Why Indiana Is Ready for the AI Economy

• Cross-sector leadership: Indiana’s innovation economy spans multiple industries—all of which are actively adopting AI for real-world impact.

• Academic and research strength: With institutions like Purdue University and Indiana University leading in AI research, the state is cultivating both talent and breakthrough technologies.

• Supportive policy and infrastructure: Indiana’s public-private partnerships are creating fertile ground for AI adoption, investment, and entrepreneurship.

• Small-team, big-mission mindset: From startups to multinationals, Indiana’s culture of practical innovation and collaboration accelerates AI readiness.

As these companies demonstrate, Indiana isn’t just experimenting with AI. it’s operationalizing it at scale. Together, they form the foundation of a resilient, future-forward economy ready to lead in the age of artificial intelligence.

Indiana is not just ready for AI. Indiana is ready to lead.